Sedating medicine Adult chat template

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Antihistamines are classified into two groups – the first-generation (“sedating”) and second-generation (“non-sedating”).Sedating antihistamines cause sedation as they are highly lipid soluble and readily cross the blood brain barrier.They also act on muscarinic, alpha-adrenergic, and serotonin receptors.

Antihistamines are a class of agents that block histamine release from histamine-1 receptors and are mostly used to treat allergies or cold and flu symptoms, although some first-generation antihistamines may also be used for other conditions.

Histamine-1 receptors are also found in the brain and spinal cord, and stimulation of these receptors makes you more awake and alert.

Sedating antihistamines oppose the effects of histamine on H1 receptors in your brain, which is why they cause sedation and drowsiness.

Most second-generation antihistamines do not cause drowsiness, although some (such as cetirizine and fexofenadine), may be more likely to do so at higher dosages.

Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.

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